The best cannabis strains for anxiety – Leafly

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11 June, 2026

Everyone experiences anxiety differently—thankfully, there are many different types of cannabis strains to match this diversity of anxiety symptoms. Whether you’re looking to alleviate PTSD, OCD, or generalized anxiety disorder, there is likely a strain that can help.
Before using cannabis to take the edge off anxiety, it’s worth first familiarizing yourself with the different types of strains available to determine which sounds best for you.
After determining whether you prefer THC, CBD, or a mix of the two, you can take your strain search to the next level by exploring different terpenes—the aromatic compounds in cannabis that imbue each strain with its unique scent and possibly, to some extent, effects.
As you go through this list and experiment with different strains, take note of which cannabinoids and terpenes your body gravitates towards for anxiety relief. That will make it easier to identify the types of strains you should (or shouldn’t) try going forward.
And last of all, we encourage you to keep your doctor in the loop if you choose to use cannabis therapeutically, especially if there are treatment or medication interactions to consider.
Patients have used this 50-50 hybrid on anxiety since the ’90s. The Blueberry calms down the Haze genetics, resulting in something pleasant and functional.
We think the terpene caryophyllene plays a role in capping the anxious effects of this popular high-THC strain. About 29% of reviewers report GSC works for anxiety.
This popular indica hybrid has long-been a go-to for relaxing after a long day’s work.
A relative of OG Kush, Bubba Kush has long brought relaxing relief to fans of indica hybrids.
One of the most popular cultivars in America for a reason—Wedding Cake offers afternoon and evening relaxation in a high-THC, vanilla cake format.
DJ Short’s blueberry-smelling and tasting classic is another popular option to calm down a bit. A full third of reviewers find it helpful for anxiety.
This popular, more indica relative of OG Kush works on anxiety for 35% of reviewers.
Primary terpenes: Myrcene, pinene, caryophyllene
Cannabinoid profile: CBD-dominant
CBD takes the wheel with ACDC, guiding you toward a calm and centered headspace without that strong cannabis high. Find space to relax and breathe and as you inhale and exhale the soothing gifts ACDC has to offer.
Primary terpenes: Myrcene, caryophyllene, pinene
Cannabinoid profile: THC-dominant
Granddaddy Purple eases you into a peaceful mindset while urging your body to release all that stress and tension. Sink in and let a blissful mindset take over.
Primary terpenes: Myrcene, pinene, caryophyllene
Cannabinoid profile: Balanced THC/CBD
Not everyone wants to get stoned out of their gourd every time their anxiety symptoms flare up. Luckily, there are strains like Canna-Tsu that offer gentle effects that are easier to manage. Find that peaceful mindset without the worry of overdoing it with too much THC.
Primary terpenes: Myrcene, pinene, caryophyllene
Cannabinoid profile: CBD-dominant
Remedy is a no-frills cannabis strain with one purpose: to walk you calmly through your anxiety toward a more peaceful mindset. A few puffs of this aptly named CBD strain can help you reach a sense of lightness in your mind as the burden of worry lifts.
So there’s some strains helping folks with their anxiety. Of course, your mileage may vary, and there’s nothing wrong with a little trial and error. Always start with just a little bit and see how it feels after 60 minutes in.
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* Statements made on this website have not been evaluated by the U.S. Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Information provided by this website or this company is not a substitute for individual medical advice.

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