The best cannabis strains for depression – Leafly

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11 June, 2026

Updated 10/1/19
Depression is a complex disorder, and cannabis is a complex plant. Research has yet to demystify the relationship between the two, and that’s an important consideration for those suffering from depression.
Despite these complexities, there are individuals who claim that cannabis helps them through depression. For some, cannabis can imbue the mind with an elevated sense of engagement and motivation. It can stimulate hunger, conversation with friends, and interest in hobbies and creative escapes. We highly encourage you to communicate with your medical professional to determine how cannabis may interfere with your current treatments and medications.
It’s important to recognize that cannabis doesn’t serve everyone. If you find that cannabis is becoming a burden on your journey, it’s okay to set it aside temporarily or for the long haul.
And finally, remember that not all cannabis strains are equal:
As you explore new cannabis strains, pay attention to the terpenes (colors) that make up your favorites. These aromatic compounds are important to your experience as they shape the aroma, flavor, and potentially even the effects associated with different strains.

Related
Try these limonene cannabis strains for anxiety, depression, and stress relief


cinex cannabis strain


Primary terpenes: Limonene, caryophyllene, pinene
Cannabinoid profile: THC-dominant
Known for its creative stimulation and lightweight effects, Cinex can rekindle interest in the hobbies you love (and maybe in the ones you didn’t know you loved!). Cinex leads with the citrusy terpene limonene, which is being studied for anxiety and depression relief.

jack herer cannabis strain


Primary terpenes: Terpinolene, caryophyllene, pinene
Cannabinoid profile: THC-dominant
Jack Herer is a strain cherished for its uplifting qualities that inspire happiness and creativity. With an aroma of sharp pine and freshly cut wood, Jack can provide a sense of comfort and motivation on low days.

harlequin cannabis strain


Primary terpenes: Myrcene, pinene, caryophyllene
Cannabinoid profile: Balanced THC/CBD
Harlequin balances the benefits of both THC and CBD, resulting in a strain that can deliver relief alongside a clear head. CBD helps counteract the sometimesanxiety-inducing effects of THC, so if you’re prone to nerves, Harlequin is for you.

granddaddy purple cannabis strain


Primary terpenes: Myrcene, caryophyllene, pinene
Cannabinoid profile: THC-dominant
Granddaddy Purple is a soothing strain that can awaken appetite and encourage a sense of serenity throughout the mind and body. This strain is best saved for late nights when you need a little help finding a cool, calm headspace before bedtime.

cannatonic cannabis strain


Primary terpenes: Myrcene, pinene, caryophyllene
Cannabinoid profile: Balanced THC/CBD
Cannatonic is anotherhigh-CBD strain that delivers you to bliss without the anxiety often associated with high-THC strains. If THC makes you feel sluggish or hazy, consider the clarity and unencumbered relief Cannatonic offers many consumers.

xj-13 cannabis strain


Primary terpenes: Terpinolene, caryophyllene, pinene
Cannabinoid profile: THC-dominant
With its bright citrusy aroma, XJ-13 has a way of throwing color back into the world and sharpening the senses. If you’re looking to invite curiosity, creativity, or a social spark back into your mind, you might consider this sweet, uplifting strain.

blackberry kush cannabis strain


Primary terpenes: Myrcene, limonene, caryophyllene
Cannabinoid profile: THC-dominant
Can’t seem to shake those late-night thoughts keeping you up? Let Blackberry Kush ease you into sleep with its meditative tranquility that helps you find stillness in mind and body.
Use the Leafly Explorer to find more cannabis strains that have been rated highly by other Leafly users for related symptoms:
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* Statements made on this website have not been evaluated by the U.S. Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Information provided by this website or this company is not a substitute for individual medical advice.

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